APA
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Ramírez–Parada, K., Sánchez, C., Cantarero–Villanueva, I., Reyes, Á., Pinto, M. P., Bravo, M. L., … Merino, G. (2025). Randomized Trial Assessing Prospective Surveillance and Exercise for Preventing Breast Cancer-Related Lymphedema in High-Risk Patients. Archives of Physical Medicine and Rehabilitation.
Chicago/Turabian
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Ramírez–Parada, Karol, César Sánchez, Irene Cantarero–Villanueva, Álvaro Reyes, Mauricio P. Pinto, M. Loreto Bravo, Denise Montt–Blanchard, et al. “Randomized Trial Assessing Prospective Surveillance and Exercise for Preventing Breast Cancer-Related Lymphedema in High-Risk Patients.” Archives of Physical Medicine and Rehabilitation (2025).
MLA
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Ramírez–Parada, Karol, et al. “Randomized Trial Assessing Prospective Surveillance and Exercise for Preventing Breast Cancer-Related Lymphedema in High-Risk Patients.” Archives of Physical Medicine and Rehabilitation, 2025.
BibTeX Click to copy
@article{karol2025a,
title = {Randomized Trial Assessing Prospective Surveillance and Exercise for Preventing Breast Cancer-Related Lymphedema in High-Risk Patients.},
year = {2025},
journal = {Archives of Physical Medicine and Rehabilitation},
author = {Ramírez–Parada, Karol and Sánchez, César and Cantarero–Villanueva, Irene and Reyes, Álvaro and Pinto, Mauricio P. and Bravo, M. Loreto and Montt–Blanchard, Denise and Acevedo, Francisco and Walbaum, B. and Alfaro-Barra, Margarita and Barra-Navarro, Margarita and Muñoz-Flores, Scarlet and Pinto, Constanza and Muniz, S. and Contreras–Briceño, Felipe and Merino, T. and Merino, Gina}
}
OBJECTIVE to evaluate if combining prospective surveillance model (PSM) with a supervised multimodal exercise program prevents breast cancer-related lymphedema (BCRL) and its impact on the functional capacity and quality of life (QoL) of high-risk breast cancer (BC) patients undergoing treatment.
DESIGN two-arm parallel superiority randomized controlled trial.
SETTING outpatient physical therapy service in a public hospital.
PARTICIPANTS 116 adult women (≥18-year-old) diagnosed with stage I-III BC were enrolled. Inclusion criteria included recent surgery and indication for adjuvant chemotherapy. Exclusion criteria were significant arm volume difference, previous cancer, exercise contraindications, and extreme BMI values.
INTERVENTIONS participants were randomized into experimental (n=61) or control groups (n=55) in a 1:1 ratio. The experimental group received PSM with a supervised multimodal exercise program for 12 weeks. The control group received PSM alone.
MAIN OUTCOME MEASURES arm volume, grip strength, 6-minute walk test, and QoL were blindly assessed at baseline, 3, 6, and 9 months.
RESULTS the combination of PSM with a supervised multimodal exercise program significantly reduced arm volume and body weight and improved grip strength, functional capacity, and the QoL of patients.
CONCLUSION combining PSM and physical exercise reduces arm volume, prevents BCRL, and improves physical performance and QoL in high-risk patients. The combination of PSM and STRONG-B was superior to PSM alone, validating the study's superiority design.